Dec. 21, 2025 at 1:43 PM ET6 min read

Amicus Therapeutics’ Stock Jumps 30% After BioMarin Acquisition

Tim BohenAvatar
Written by Tim Bohen
Reviewed by Ben Sturgill Fact-checked by Ellis Hobbs

Amicus Therapeutics stocks have been trading up by 30.03 percent, boosted by promising FDA designations and results.

Key Highlights from Recent Developments

  • On December 19, it was announced that Amicus is being acquired by BioMarin Pharmaceutical for $14.50 per share. This all-cash transaction implies a valuation of approximately $4.8 billion.
  • The deal represents a significant premium on Amicus’ market value, with shareholders expected to benefit upon the deal’s anticipated closure in the second quarter of 2026.
  • Following the acquisition news, Amicus’ stock experienced a surge of over 30%, reflecting strong investor support and optimism surrounding the transaction.
  • Additionally, Amicus reached a settlement on a patent litigation with Aurobindo Pharma and Lupin, allowing the sale of generic Galafold starting in 2037.
  • Citi has also projected a positive outlook for Amicus, setting a $17 price target due to the potential of their rare disease therapies to surpass $1B in sales by 2028.

Healthcare industry expert:

Analyst sentiment – positive

Market Position & Fundamentals:

Amicus Therapeutics (FOLD) has established a solid market position primarily driven by its high gross margin of 89.8%, evidencing operational efficiency. However, profitability metrics are challenging, with negative pretax and total profit margins of -35.5% and -2.35%, respectively. The company’s revenue stands at $528.3 million, with a commendable growth rate of 22.8% over three years. Its valuation remains intensive, with a price-to-sales ratio of 7.31 and price-to-book at 18.99. Despite operational cash flow of $35.66 million, high debt levels, evidenced by a total debt-to-equity ratio of 1.92, constrain overall financial agility, reflecting moderate financial strength.

Technical Analysis & Trading Strategy:

Recent price patterns for Amicus Therapeutics indicate a volatile price movement with a spike on December 19, as the stock jumped to $14.16, reflecting a robust upward trend. This breakout from previous price consolidation around $11 suggests bullish momentum supported by increased volumes. The dominant trend is positive, with the sharp ascent on December 19 likely tied to acquisition news. Given the current bullish sentiment, a suitable strategy would be to enter on pullbacks close to $14, with a target price reflecting BioMarin’s acquisition offer of $14.50. Vigilant monitoring near the $13-$14 range could provide optimal entry points, avoiding premature exits during minor volatility.

Catalysts & Outlook:

A pivotal catalyst is BioMarin Pharmaceutical’s acquisition of Amicus Therapeutics for $14.50 per share, amounting to an equity value of approximately $4.8 billion, delivering a substantial premium over FOLD’s prior closing price. This acquisition aligns with Amicus’s strategic product expansion in rare disease therapies. Despite potential investigations into fiduciary missteps, the acquisition approval by both boards and a favorable analyst coverage with a $17 price target by Citi provide confidence in enhanced shareholder value. With the stock rallying by more than 30% post-announcement, Amicus showcases significant potential relative to industry benchmarks, bolstered by resolution of pending patent litigation. Successfully closing this acquisition could serve as a significant anchor for outperforming in the healthcare sector, especially if support holds above key psychological levels around $14.21.

Candlestick Chart

Weekly Update Dec 15 – Dec 19, 2025: On Sunday, December 21, 2025 Amicus Therapeutics Inc. stock [NASDAQ: FOLD] is trending up by 30.03%! Discover the key drivers behind this movement as well as our expert analysis in the detailed breakdown below.

Quick Financial Overview

The financial dynamics surrounding Amicus Therapeutics demonstrate compelling momentum, particularly highlighted by the recent acquisition announcement by BioMarin. In recent market movements, Amicus soared from $10.91 per share to $14.16, fueled by the acquisition news. This reflects a strong uptrend reinforced by a robust acquisition premium.

Examining the financials, Amicus exhibits a notable gross margin of 89.8%, indicating strong profitability fundamentals. However, with a negative pre-tax profit margin of -35.5%, the company faces challenges in overall profitability from operations. The stock trades with a price-to-sales ratio of 7.31 and a price-to-book ratio of 18.99, positioning it on the higher end of valuation metrics, indicative of the market’s speculative optimism following acquisition announcements.

Amicus’ recent quarterly report further reveals a healthy cash position with ending cash amounts to $193.86M, improved operational cash flow, and disciplined capital expenditures. These metrics convey that while the current operational income stands at $34.27M, strategic maneuvers, such as the BioMarin acquisition, aim to unlock further value.

The acquisition news galvanizes a strategic direction for Amicus, especially as it streamlines its focus on rare disease treatments projected to hit $1B in sales over the coming years. The impact of the deal is clear: a refreshed market break aligning operational strategies with anticipated value augmentations.

Conclusion

As the acquisition unfolds, the implications for Amicus Therapeutics are profound, elevating market standing amidst the complex tides of pharmaceutical trades and trading landscapes. The surge in Amicus’ stock signals robust trader assurance and a tangible foothold in achieving transformational growth through this acquisition. Strategic engagements, coupled with solid financial planning and operational improvements, lay the groundwork for an advantageous future trajectory. As Tim Bohen, lead trainer with StocksToTrade, says, “A good trade setup checks all the boxes—volume, trend, catalyst. Don’t trade if you’re missing pieces of the puzzle.” With strong sentiment set across stakeholder targets, this acquisition heralds a defining moment in Amicus’ corporate evolution, aimed at enhancing shareholder value and competitive sustainability over time.

This is stock news, not investment advice. StocksToTrade News delivers real-time stock market updates tailored to highlight the key catalysts driving short-term price movements. Our coverage is designed for active traders and investors who thrive in fast-moving markets, with a focus on volatile sectors like penny stocks, AI stocks, Robinhood stocks and other momentum plays. From earnings reports and FDA approvals to mergers, new contracts, and unusual trading volume, we break down the events that can spark significant price action.

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